> biosketch()

Check out my about.me profile.

> education()

PhD: Genetics, Molecular and Cellular Biology
---2006-2011: University of Southern California (USC)

MSc: Bioinformatics
---2005-2006: Johns Hopkins University (JHU)

MSc: Biology
---2001-2003: California State University, Los Angeles (CSULA)

BSc: Physiological Science and History
---1994-1999: University of California, Los Angeles (UCLA)

> current_projects()

* Integrating Next Generation Sequencing data (RNAseq, ChIPseq and clinical phenotype) to understand and characterize functional Single Nucleotide Polymorphisms (SNPs) associated with risk in human cancers.
* Analyzing and interpreting Human Epigenomic data, specifically aberrant DNA Methylation associated with Human Cancers (e.g. Brain, Colon, Prostate, Bladder, Ovarian, Breast cancers, etc.). See [The Cancer Genome Atlas -- TCGA or wiki]

> publications()

* Doctor of Philosopy (PhD) (2011):
Integrating Epigenomic Data of Glioblastoma Multiforme: Method Development & Application.
University of Southern California, Los Angeles. [March 30, 2011]

* Masters of Science (MS) (2003):
Human Pancreatic Islets Express Fatty Acid Translocase (FAT/CD36).
California State University, Los Angeles.


1. Noushmehr H, Coetzee SG, Rhie SK, Yan C, Coetzee GA. Book title: Androgen-Responsive Genes in Prostate Cancer (Edited by Zhou Wang). Chapter Title: The Functionality of Prostate Cancer Predisposition Risk Regions is revealed by AR Enhancers. Springer In press (2013).

See current pubmed listing here or Google Scholar Citation.

1. Coetzee SG, Rhie SK, Berman B, Coetzee GA, Noushmehr H. FunciSNP: An R/Bioconductor Tool Integrating Functional Non-coding Datasets with Genetic Association Studies to Identify Candidate Regulatory SNPs. Nucleic Acids Research 40(18):e139, 2012

2. Yang X, Noushmehr H, Han H, Andreu-Vieyra C, Liang G, Jones PA. Gene reactivation by 5-Aza-2'-deoxycytidine induced demethylation requires SRCAP-mediated H2A.Z insertion to establish nucleosome depleted regions. PLoS Genetics 8(3):e1002604, 2012

3. Little GH, Noushmehr H, Baniwal S, Berman BP, Coetzee GA, Frenkel B. Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Research 40(8):3538-47, 2012

4. Noushmehr H and Coetzee GA. Identification and Functional Annotation of GWAS Risk SNPs. Cell Cycle 10(23):3995-6, 2011

5. Berman BP, Weisenberger DJ, Aman JF, Hinoue T, Ramjan Z, Liu Y, Noushmehr H, Lange CPE, van Dijk CM, Tollenaar RAEM, Van Den Berg DJ, Laird PW. Regions of Focal DNA Hypermethylation and Long-Range Hypomethylation in Colorectal Cancer Coincide with Nuclear Lamina-Associated Domains. Nature Genetics 44(1):40-6, 2011

6. Cancer Genome Atlas Research Network (TCGA), Laird PW., Shen H, Weisenberger DJ, Noushmehr H, Pan F, Triche T Jr, Berman BP, Van Den Berg DJ, Buckley J. Integrated Genomic Analyses of Ovarian Carcinoma. Nature 474(7353):609-615, 2011

7. Hinoue T, Weisenberger DJ, Lange CPE, Shen H, Byun H, Berg DVD, Malik S, Pan F, Noushmehr H, Dijk CMV, Tollenaar RAEM, Laird PW. Genome-scale analysis of aberrant DNA methylation in colorectal cancer. Genome Research 22(2):271-82, 2011 (online); 2012 (press)

8. Noushmehr H, Weisenberger DJ, Diefes K, Phillips HS, Pujara K, Berman BP, Pan F, Pelloski CE, Sulman EP, Bhat KP, Verhaak RG, Hoadley KA, Hayes DN, Perou CM, Schmidt HK, Ding L, Wilson RK, Van Den Berg D, Shen H, Bengtsson H, Neuvial P, Cope LM, Buckley J, Herman JG, Baylin SB, Laird PW, Aldape K, Cancer Genome Atlas Research Network (TCGA). Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma. Cancer Cell 17(5):510-522, 2010

a. Commented in Cancer Cell, 17(5), p. 419-20. 2010 (May)
b. Highlighted in Nature Genetics, 42(6), p. 481. 2010 (May)
c. Commented in Cancer Research, 70(19), p7372-78. 2010 (Oct)
d. Evaluated in Faculty of 1000, F1000.com/7792960. 2011 (Jan)

9. Teschendorff AE, Menon U, Gentry-Maharaj A, Ramus SJ, Weisenberger DJ, Shen H, Campan M, Noushmehr H, Bell CG, Maxwell AP, Savage DA, Mueller-Holzner E, Marth C, Kocjan G, Gayther SA, Jones A, Beck S, Wagner W, Laird PW, Jacobs IJ, Widschwendter M. Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Research 20 (4): 440-6, 2010

10. Brown J, Snir M, Noushmehr H, Kirby M, Hong SK, Elkahloun AG, Feldman B. Transcriptional profiling of endogenous germ layer precursor cells identifies dusp4 as an essential gene in zebrafish endoderm specification. Proceedings of the National Academy of Sciences 105(34):12337-42, 2008

11. Pei W, Noushmehr H, Costa J, Ouspenskaia MV, Elkhaloun AG, Feldman B. An Early Requirement for Maternal FoxH1 during Zebrafish Gastrulation. Developmental Biology 310(1):10-22, 2007

12. Noushmehr H, DAmico E, Farilla L, Hui H, Wawrowsky KA, Mlynarski W, Doria A, Abumrad NA, and Perfetti R. Fatty Acid Translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic beta cells and mediates fatty acid effects on insulin secretion. Diabetes 54(2):472-81, 2005

13. Farilla L, Bulotta A, Hirshberg B, Li Calzi S, Khoury N, Noushmehr H, Bertolotto C, Di Mario U, Harlan DM, and Perfetti R. GLP-1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology 144(12):5149-58, 2003

> contact()

Present Address:
University of Sao Paulo
School of Medicine, Ribeirao Preto
Department of Genetics
Ribeirao Preto, Sao Paulo, Brazil
Av Bandeirantes, 3900
Ribeirao Preto, SP, Brasil

houtan {at} usp {dot} br

> links()

* USC Epigenome Center
* Google + Profile
* LinkedIN Profile
* The Cancer Genome Atlas -- TCGA
* USC Researchers Discover New Molecular Subtype of Brain Cancer
* Mendeley Profile

> agenda()

Currently we have 70 confirmed students.